WormClassroom

The aim of this lab is to investigate the genetic basis of innate immunity. That means gaining insight into processes that make hosts either resistant or susceptible to bacteria. Researchers are trying to find differences and similarities between immune system in the worm and the vertabrate immune system.

This lab is investigating germ cell fates. They are interested in questions such as what factors trigger meiosis or mitosis in cell and what causes germ cells to differentiate either into oocytes or sperm.

Website focused on polarity in embryo development, especially during the first cell division. The research of interest includes determining how asymmetrical division works in the zygote.

This lab studies the synaptonemal complex – a structure found during meiosis. Assembly of this structure may be studied in C.elegans because its germ line cells account for more than a half of the cells in the worm.

Study of DNA damage signaling, cell cycle and apoptosis in correlation with cancer tumor diagnostics. The objective is to find out what is required to initiate self-repair or self-destruction processes in cells.

This site presents movies from embryo to adult worm.

A map of the interactome network of the metazoan C.elegans.

The website is still under construction, but the lab investigates sex determination – in particular, what factors make a developing organism decide to become female or male. They are also interested in X chromosome compensation and segregation during division.

The research focus is on muscle development in C. elegans, with emphasis on proteins that make up a sarcomere.

It is a special project conducted by NASA based on effects of spaceflight on C. elegans, with emphasis on tissue development, cell apoptosis, muscle physiology and gene expression.

Researchers in the Seydoux lab study mechanisms that distinguish the formation of somatic cells from germ cells in C. elegans. One of the projects investigates molecular regulators responsible for germ cell fate, another focuses on protein degradation in determining embryonic polarity.

This website provides a study of mechanisms and regulators of apoptosis in C. elegans. Research is based on genes that decide about cell fate. The second part of research is aimed at understanding the development and roles of glial cells (a poorly understood but common cell type in the human brain).

Website on the role of genes in germ cell development. The focus is on the distal tip cell (DTC) (a structure that determines when germ cells should enter meiosis) and genes that are crucial for other stages of meiosis. Shedl Lab is also interested in molecular determinants of gender.

Researchers in this lab are studying mutations characteristic only for germ cells. They are trying to understand the processes occurring at fertilization and the genes that are involved.

The main interest of the lab is the positioning organelles in cell. The Starr Lab is trying to identify proteins that contribute to nuclear migration and understand its importance.

How does development from a single cell to a complicated organ occur? This includes investigations on cell-signaling in the formation of left-asymmetry as well as apoptosis regulation.